Cancer Immunoresistance Linked To Loss Of Tumor Suppressor Gene

Cancer immunoresistance may be partially due to loss of a well-known tumor suppressor gene. It has been known for a long time that cancer cells have many different ways to avoid the immune system, including the common strategies of hiding proteins that are normally expressed on the cell surface or making proteins that act to suppress immune responses. Some researchers believe that immunoresistance may contribute to cancer progression and development. Over the past four years, Parsa's lab has focused on trying to understand how specific mutations associated with high grade glioma correlate with immunoresistance.