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It's long been known that experiencing control over a stressor immunizes a rat from developing a depression-like syndrome when it later encounters stressors that it can't control. Now, scientists have unraveled the workings of the brain circuitry that inoculates against such hard knocks -- the circuitry of resilience. Control not only activated the brain's executive hub, the prefrontal cortex, but also altered it so that it later activated even when the stressor was not controllable.
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